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The occurrence of a single subject with evidence of overt hemolysis associated with an amustaline/GSH antibody would require a clinical hold with evaluation and DSMB and FDA approval to continue enrolment

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As the important oncoproteins and subunits of the transcription factor - activator protein- 1 (AP-1) in skin carcinogenesis, Jun and Fos family members have been previously studied [23]

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